Mosaicism describes an individual composed of two or more genetically. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. It is feasible that the latter may. 1,2 There are several terms for this entity, including linear LP, Blaschkolinear LP, and Blaschkoid LP. The conductor of Blaschko represent ampere pattern assumed by multiple different nevoid and acquired skin diseases on the human. Blaschko's lines were firstly described by Alfred Blaschko in 1910. They follow a “V” shape over the back,. 4 Blaschko lines are invisible in normal skin but may become apparent in various skin conditions. The eruption affects the lines of Blaschko, which are thought to be embryonic in origin. Thomas et al. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow. The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. All humans have Blaschko’s lines, but they are usually not visible. 24% to 0. Yeah, there were multiple things of vanilla ice cream and now they're one thing, but it's all vanilla ice cream. Cutaneous lesions following Blaschko lines are a manifestation of cutaneous mosaicism. The nevi on the skin can be scattered or densely distributed keratinizing papules, with a small pit in the center. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. The concept of Blaschko’s lines were first introduced by Alfred Blaschko in 1901. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. The most common presenting symptoms of classical LS may include dryness and pruritis ranging to mild to severe. Interestingly, our patient showed multiple ACC lesions, which were located along Blaschko’s lines. Noun [edit] Blaschko's lines pl (plural only) Lines of normal cell development in. 3 The term “linear cutaneous lupus ery-thematosus” was later proposed by Abe et al. 人体皮肤上有一种叫做Blaschko线的条纹，这些线是人体胚胎发育时细胞运动路径的痕迹，通常是看不见的。. How do you say Blaschko lines? Listen to the audio pronunciation of Blaschko lines on pronouncekiwi. Lines of Blaschko are usually invisible unless genetic mutations result in mosaicism that alters the pigmentation, proliferation, and/or differentiation of epidermal cells. Method: One hundred eighty-six figures showing skin lesions following Blaschko's lines on the head and neck were collected from literature and patient files,. Jackson: The lines of Blaschko: a review and reconsideration: Observations of the cause of certain unusual linear conditions of the skin. These were first described by Alfred Blaschko in 1901. Blaschko's Lines. Noun [edit] Blaschko's lines pl (plural only) Lines of normal cell development in the skin, which become visible in certain diseases. Something went wrong. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. Typically these lines are not visible; however. , 2005) and the karyotype of a woman with body asymmetry and patchy skin was mos 45,X/46XX,+14 (Becerra-Solana et al. 1, 2 The nevi are generally unilateral, following Blaschko lines in linear. Expand [PDF] Save. Blaschko’s lines are a fascinating part of our genetic code and a reminder of the complexity and diversity of the human body. Extragenital LS can occur in children as sclerotic atrophic plaques, most often appearing on the trunk and lower extremities . Blaschko’s lines. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. Blaschko’s lines were originally described by Dr. 3. To our knowledge, the dermatoscopic features of pigmented lesions in LWNH have not been described previously. A Case of Segmental Vitiligo Along Blaschko's Lines. Lesions can appear anywhere, but the sites most commonly affected are the fingers and wrists, axillae, groin, and genitalia, and the skin around the eyes and mouth. Mosaic individuals are composed of two. Each patch of linear psoriasis represents one cell and all of the copies that it made. The causes for occurrence in a linear pattern include lesions following Blaschko's lines, blood vessels, lymphatics and dermatomes; due to Koebner’s phenomenon and auto inoculation; external factors; infestations like cutaneous larva migrans and burrows of scabies. Line of Blaschko. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Blaschko’s lines are invisible lines that are present on healthy skin. The diagnosis and management of lichen. What are Blaschko’s lines on our skin? How can you see them? - Quora. He noticed that some of his patients had skin disorders that followed a specific. On the chest and upper back they rise in a swirl before. The first girl presented at age 4 months with a history of the pigmentation beginning at age 1. TLDR. A 32-year-old Taiwanese man presented to our clinic with a 6-month history of linear hair loss in a wavy and curved pattern across the parietal and occipital scalp, resembling the distribution of Blaschko's lines. The peripheral rim can be translucent or slightly pigmented and centre can have dotted vessels or blue/gray dots/granules based on the. Blaschko′s Lines. Both HI and LWNH encompass heterogeneous groups of disorders characterized by conditions with hypopigmented or hyperpigmented skin. These lines are only visible in those with a mosaic The lines are believed to trace the migration of embryonic cells. They were described and drawn by Blaschko 75 years ago. The main event which allows the existence of mosaicism is a genetic mutation, either structural or functional. Although cases of lichen planus (LP) are not uncommon, LP with lesion distribution along the Blaschko’s lines is a rare entity, accounting for only 0. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Blaschko's lines also termed as the lines of Blaschko, are believed to represent normal cell development in the skin. A dermatome is an area of skin that is supplied by a single spinal nerve. These lines are invisible under normal conditions. Start your 7-day free trial to. Blaschko's lines form a pattern, which many diseases are found to follow, but linear scleroderma following Blaschko's lines is a controversial entity rarely reported in the literature. They follow a “V” shape over the back, “S. They follow a dorsal “V” shape over the spine and back, an “S” shape over the lateral and anterior areas of the trunk, an arc from the chest to the shoulders, a spiral shape on the scalp, and a linear longitudinal pattern on the extremities. 发音 blaschko's lines 2 音频发音, 更为 blaschko's lines. Blaschko's lines were firstly described by Alfred Blaschko in 1910. Lichen planus; Blaschko’ lines; Lichen planus involving nails; Case report: Core Tip: Lichen planus (LP) with lesion distribution along the Blaschko’s lines can be differentiated from other skin lesions with linear distribution by dermoscopy and pathological biopsy. Treatment with 2% topical minoxidil twice a day produced gradual elongation and thickening of the affected hairs with considerable cosmetic. Mosaicism describes an individual composed of two or more genetically different. The lines were discovered by German dermatologist Alfred Blaschko 75 years ago, Dr Bav Shergill, of the British Association of Dermatologists told MailOnline. The lines of Blaschko, which are normally invisible on skin, are thought to follow the paths along which cells migrate as the skin develops before birth. Typical humans don't have significantly different genetic material in different strips of skin. Epidermal FIGURE 1 Clinical features and histopathological findings. In fact, these are leftover from the time the person was a baby growing in the womb. Vitiligo is a common acquired depigmenting disorder of the skin and mucosa, affecting 0. A dermatome is an area of skin that is primarily supplied by a single nerve root: communicating sensation from this skin region to the brain. The nowadays well-known lines of Blaschko form streaks displaying a V-shape or fountain-like pattern on the back, an S-shape or whorled pattern over the lateral aspects of the trunk, and a linear pattern on. Neither a specific disease nor a predictable symptom of a disease, Blaschko's lines are an invisible pattern built into human DNA [citation. Blaschko's lines refer to the S-shaped or V-shaped whorled, streaked, and linear patterns that are recognized in many different cutaneous disorders. They run down the arms and legs and curve around the sides like tiger stripes. We provide a simplified approach for the diagnosis of linear hyperpigmentation through two steps: 1 To determine whether hyperpigmentation follows Blaschko’s lines;. [French, from past participle of blaser, to cloy, from French dialectal, to be chronically hung over, probably from Middle Dutch blāsen, to blow up, swell; see bhlē- in. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. Over 50% of cases occur in children aged between 5 and 15 years. He recognized the pattern as distinct from dermatomes and Langer lines. TLDR. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. Mosaic skin conditions are conditions where the skin is composed of two or more genetically different cell lines, resulting in patches of differently colored skin. These lines are invisible under normal conditions. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. These preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if. These lines create a surface pattern which is distinct from other morphological lines. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. ( Bygum et al. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. We described herein an 18-month-old male patient with KD who presented with linear, facial erythema coinciding with Blaschko’s lines. BACKGROUND Linear atrophoderma of Moulin (LAM) is a dermatosis that affects children and adolescents characterized by hyperpigmented and atrophic. ” No conditions following Blaschko's lines in narrow bands had a genetic abnormality. 1,2 To the best of our knowledge, there is no existing clinical approach for linear hyperpigmentation diagnosis. Acquired blaschkoid dermatitis is unilateral — it only affects one side of the body. The images in this gallery page should be true SVG Blaschko's lines, patterns 3D shaded illustrations without any embedded bitmap . We report two cases of localized, unilateral, linear LP hypertrophicus along the lines of Blaschko. This case presented with mild symptoms of MPS such as hepatosplenomegaly, joint stiffness, and quite mild bone deformity, which was the reason for the delay in diagnosis until the age. Blaschko’s lines were originally described by Dr. Mutations involving color-producing cells can lead to pigmentary mosaicism presenting as streaks and swirls following Blaschko lines. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. The lines of Blaschko represent the routes of ectodermal cell migration from the neural crest. The distribution of skin conditions along Blaschko’s lines that involve dermal processes is thought to be due to epidermal mutations that lead to changes in dermal tissues. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. A minimal number of patients may have generalized skin lesions. Lines of Blaschko doi: 10. Possibly genetic factors or environmental triggers have a role to play in its development. These stripes, which are known as Blaschko’s lines, were discovered by dermatologist Alfred Blaschko in 1901. 2. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. 1A, B). Here is a partial list of other materials that glow: Petroleum jelly, such as Vaseline, glows a bright blue color under a fluorescent light. They also run along the face above and below the eyes and over the ears. 4 The palms, soles, scalp, and mucous membranes are typically spared. Four other patterns of mosaicism are also di. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. The histopathologic analysis of a skin biopsy in conjunction with the anamnesis allowed the diagnosis of. S. Finally, we differentiate Blaschko's. This is also a rare case in which 90% repigmentation was achieved in patient with segmental and nonsegmental vitiligo following Blaschko. Most of them are nevoid skin lesions present at birth or having a later onset: epidermal nevi (naevus unius lateris, linear porokeratosis), adnexal nevi (linear sebaceous nevus, linear. Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. The present CME article will highlight important. We. Linear and whorled nevoid hypermelanosis (LWNH) is a reticulate pigmentary disorder characterized by hyperpigmented macules in a streaky configuration, evolving along Blaschko's lines [ 1, 2, 3 ]. Blaschko's lines were first described by Alfred Blaschko in 1901 and are thought to reflect patterns of cell migration and clonal expansion during the embryonic development of the epidermis [2. The lines were discovered by German dermatologist Alfred Blaschko 75 years ago, Dr Bav Shergill, of the British Association of Dermatologists told MailOnline. Most often diagnosed during infancy because of the striking cutaneous findings that typical follow Blaschko lines. Some acne-like horny plugs in the center of the papules merge into plaques. Exogenous linear patterns are caused by external factors. Fig 4 Acne on the back at age 19 years, with scarring more. LPP along Blaschko's lines has been associated with susceptibility to genetic mosaicisms. A 56-year-old woman presented with a 3-month history of erythematous plaques covered by scales and limited to the right side of her body. They are clinically important, as many inherited and acquired diseases follow these lines, making a characteristic visual appearance. He noticed that some of his patients had skin disorders. When we start out as a single cell, and then a ball of cells, some of these cells become skin cells. Unilateral distribution of lesions in arm, leg, trunk, and waist is even less common. All humans have Blaschko’s lines, but they are usually not visible. They may be either visible at birth or become manifest dur - ing the first years of life. Lichen striatus (LS) is an uncommon linear dermatosis that most commonly affects children aged 4 months to 15 years and is distributed along the lines of Blaschko. The present author previously proposed that in addition to the line of migration, proliferation pattern of the embryonic cells at some later stage might have. Some patterns were restricted to. Out of the 3 reported cases of linear LSA that appeared on the face, one case showed facial lesion following the Blaschko's line without any oral mucosal lesion, and the other 2 cases showed additional oral mucosal. The main differential diagnoses are the other linear dermatoses that run along Blaschko's lines, especially an inflammatory linear verrucous epidermal naevus (ILVEN), however, when compared to lichen striatus, ILVEN have the following characteristics: 75% of lesions arise during the first five years of life, most often in the first six monthsBlaschko lines are distinctive whorled and linear patterns on the skin first described by the dermatologist Alfred Blaschko in 1901. It is generally noted at birth and stabilizes with 1–2 years of progression. The original description by Blaschko referred to a system of lines on the human skin which the linear naevi and dermatoses follow. Flag-Like PatternThe stripes are called Blaschko’s lines, after the German dermatologist Dr Alfred Blaschko, who first described them in 1901. Males and females have Blaschko's lines. Recent studies have suggested that these linear pigmentary anomalies reflect underlying genetic mosaicism. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Last updated October 06, 2023. Net Letter Nevus comedonicus along Blaschko’s lines Sir, groups of dilated follicular openings filled with black, Nevus comedonicus is an uncommon skin abnormality hard plugs, distributed over left cheek, left arm and first described in 1895 by Kofmann who used the term forearm, left side of the chest [Figure 1], abdomen, left “comedo-nevus”. 起病突然，数周内全面进展，通常在6-12个月内消退。. Inherited factors in the affected skin, rather. have reported the case of a 48-year-old patient with three clinical subtypes [ 12 ], while Vineet et al. Fig 3 Cerebriform connective tissue nevus present on the soles at age 17 years. Unconcerned; nonchalant: had a blasé attitude about housecleaning. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Inherited factors in the affected skin, rather. Alfred Blaschko是一位德国皮肤科医生，他收集了一. It is not present at birth, hence the term 'acquired'. The lines of Blaschko represent a pattern followed by many skin disorders. Can be smooth or verruciform. Finally, we differentiate Blaschko's. 1001/jamadermatol. Six archetypical patterns of cutaneous mosaicism can so far be distinguished: (1) lines of Blaschko, (2) checkerboard pattern, (3) phylloid pattern, (4) patchy pattern without midline separation, (5) lateralization pattern, and (6) the sash-like pattern (Figs. Blaschko Lines follow the same pattern on all people. Diagnosis is made based on clinical appearance of 2 to 4 mm, flat-topped, lichenoid papules ranging from red color to flesh color that are distributed linearly and may be discrete or. Typically these lines are not visible; however. TIL Human skin is overlaid with Blaschko’s Lines, a pattern of stripes covering the body from head to toe, invisible unless under UV light or if certain skin conditions manifest them mentalfloss. 1. Alfred Blaschko is credited with the first demonstration of these lines in 1901. A 24-year-old man presented with multiple linear, atrophic, hyperpigmented lesions punctuated by areas of depigmentations on the left half of the trunk. Acquired blaschkoid dermatitis is unilateral — it only affects one side of the body. 3A 27-year-old Japanese woman presented with small atrophic hyperpigmented macules on her extremities since early childhood. Iijima et al. Skincondition Characteristics. different dermatoses, but the cause of this Revised version accepted 3 June 1993. We received the patient's consent form about publishing all photographic materials. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Type 1a and 1b in the image below are the most typically seen. Cases related to atopic diathesis are common. BACKGROUND The system of Blaschko's lines has been insufficiently documented on the head and neck. Multiple lesions arise in a linear fashion along the lines of Blaschko, most commonly along a limb or one side of the trunk or head and neck ; Disseminated superficial actinic porokeratosis (DSAP) This is the most common variety and arises in. 5-1 cm hypopigmented or white macules that merge to form larger patches; Macules cover more than two dermatomes and are often on both sides of the body; Patches are not symmetricalFor example, Blaschko's lines were present in a girl with a karyotype mos 47,XX,+7/45,X (Niessen et al. It is characterised by asymptomatic, hyperpigmented papules and plaques that have a peripheral, net-like configuration. These lines were painstakingly and thoroughly documented first by German dermatologist Alfred Blaschko. Several examples of chekerboard or patch patterns on human skin are seen in several human diseases (Happle, 1995, 2004). Blaschko’s lines. and mucous membranes. Disease with presentation along Blaschko’s lines Dermoscopic features; Porokeratosis: Well-defined peripheral white-coloured rim with two free edges continuous or broken at some parts (“white track”). 2021. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. 24%-0. This contribution provides an update on the diverse genetic etiologies, cutaneous findings, potential associated extracutaneous. Various inherited and acquired disorders of hyperpigmentation have been described along these lines. Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. Blaschko’s lines map out a migratory history of ectodermal skin cells after their proliferation and movement from embryonic development into the fully formed organism ; further, skin disorders following these lines may be explained by the mosaicism due to X-chromosome inactivation or early somatic mutations . We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. 62% of all patients. Blaschko lines presenting as narrow bands are common in mosaic disorders (e. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Blaschko line, lichen planus, Blaschkoian lichen planus, zosteriform lichen planus. These lines are consistently S-shaped on the abdomen, V-shaped on the upper spine, perpendicular along the length of the arms and legs, inverted U-shaped on the chest, and follows a more. Lichen striatus is an acquired, asymptomatic, and self-limited linear inflammatory skin disorder that predominantly affects children [ 1,2 ]. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science, and it is hoped that some inter‐reaction can occur between those who regularly see and study other chromosomal and embryological abnormalities. Lines similar to ‘Blaschko's lines’ have also been described in eyes and teeth. We. Confluent and reticulated papillomatosis is an uncommon skin condition affecting the trunk, neck and axillae. Different descriptive terms for these disorders include "linear and whorled nevoid hypermelanosis" (LWNH), [1] "progressive cribriform and zosteriform. They were described and drawn by. The isotopic response can occur in patients with LP, which may be an. (a) Blaschko's lines. These lines are unique and rarely found in nature and are a result of abnormal cell migration during development in the womb. Kawasaki disease (KD) is a self-limited, systemic vasculitis developing in early childhood. On the chest and upper back they rise in a swirl before. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. These lines are. She showed small-sized or aplastic fingernails on the right hand. Correspondence to knownas Blaschko's lines. Incontinentia pigmenti, also known as Bloch-Sulzberger syndrome, is an uncommon sex-linked inherited syndrome reported primarily in females, as it is often lethal to male fetuses in utero. However, in the case of skin diseases, they develop skin lesions or eruptions such as warts. The macules spread across her body and increased in number following Blaschko’s lines (Fig. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. However, these lines can become visible if a person is suffering from a skin disease. Here, we report a case of this rare disorder and have put forward an argument why. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Pigmentary nevi represent nevi with altered pigmentation. Hypopigmented lesions following the lines of Blaschko are usually the presenting feature. Blaschko's lines. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. 1998. 11 The lines are visible and present in S-shaped, V-shaped, or even U-shaped patterns. They show up on people with chimerism, which is what those photos of somebody's back are, where there are actually different patches of tissue with different genetic material. The Blaschko’s lines result from the fact that some of a chimera's skin cells say “make darker skin” and some say “make lighter skin. A case of bilateral linear and annular lupus panniculitis following Blaschko's lines in a childConfluent and reticulated papillomatosis (CARP) is an uncommon dermatosis characterized by hyperpigmented scaly macules or papillomatous papules coalescing into confluent patches or plaques centrally with a reticular pattern peripherally ( picture 1A-D ). A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. General mosaicism: Occurs when there are two or more cell lines existing in a baby. 62% of all LP patients. The lines of Blaschko describe a linear pattern of distribution of various congenital, nevoid, and acquired skin disorders with their suspected embryological origins not yet well. Oral antibiotic therapy is the mainstay of treatment. , BMC Medical Genetics , 2011 ) Mutations involving color-producing cells can lead to pigmentary mosaicism presenting as streaks and swirls following Blaschko lines. In 1998, when reporting 2 cases of linear childhood CLE following the lines of Blaschko, Abe et al. The stripes are sort of U-shaped down our fronts and V-shaped on our backs, wavy on the head and face and we have basic simple stripes on our extremities. These lines are invisible under normal conditions. French dermatologists Gourgerot and Carteaud first described confluent and reticulated papillomatosis in 1927 [1]. 62% of all patients with LP [ 1 ]. Fig. Case summary: A 20-year-old woman presented. They were described and drawn by Blaschko 75 years ago. They only become apparent if a person’s cells make two different colors of skin. Blaschko’s Lines. Blaschko’s lines, also called the lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. These lines, which are invisible under normal conditions, indicate the normal. Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. R. Blaschko lines correlate with mosaicism, regardless of the clinical presentation. It depends on their location. 线状苔藓是获得性、炎症性皮肤病，呈自限性，皮损线状排列，无其他症状，主要发生于儿童，一般单侧发疹，最常累及四肢，沿Blaschko线连续性或间断性分布。起病突然，数周内全面进展，通常在6-12个月内消退。本专题将讨论线状苔藓的发病机制、临床表现、诊断和治疗。Cutaneous conditions can follow Blaschko's lines on the skin, which are thought to reflect patterns of cell migration and clonal expansion during embryonic development of the epidermis. (1987) reported 2 unrelated Japanese children with early-onset reticulate hyperpigmentation distributed in a zosteriform pattern along the lines of Blaschko on the trunk and limbs, but sparing the face, palms, and soles. To minimize confusion and be more consistent with its distribution, we suggest this. The human stripes are visible only under UV light but invisible to th. In this paper, we presented a 47. Discussion. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Exogenous linear patterns are caused by external factors. (C) Blaschko linear, erythematous and pigmented atrophic line with a verrucous part (6-months-old). g. The plaques were arranged along Blaschko's lines with a marked mid-line cutoff. Blaschko’s lines are actually traces of the migration and proliferation of skin cells during embryonic development. '2 DrMoss. The lesions following Blaschko's lines in PCZH may reflect the clonal migration and proliferation of embryonic melanoblasts, resulting in peculiar cutaneous patterns. Blaschko’s Lines. These lines are only visible in those with a mosaic The lines are believed to. in 1993. However, there is no report of. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. They run down the arms and legs. Not the first to mention it but yeah Blaschko's lines aren't visible to anything normally. A healthy 7-year-old girl presented to our clinic with bilateral asymmetric LS occurring on the right arm and left leg of 1-year duration. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. They may be unilateral in early non-segmental vitiligo, or in segmental vitiligo when confined to part or all of one or more dermatomes or areas delineated by Blaschko's lines. Blaschko lines are consistently V-shaped on the upper spine, S-shaped on the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. 1 He originally described these lines as “a system of lines on the human skin that linear nevi and dermatoses follow”. Verrucous lesions were present at the same time with scarce vesicles. The Blaschko’s lines result from the fact that some of a chimera's skin cells say “make darker skin” and some say “make lighter skin. Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. Unilateral distribution of lesions in arm, leg. This contribution provides an update on the diverse genetic etiologies. They run down the arms and legs. Blaschko's lines are consistently V-shaped at the top of the spine, S-shaped across the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. 1 Linear cutaneous lesions are those that occur along imaginary skin lines like Blaschko’s lines, lymphatics, and blood vessels or those with. , 2008). This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. 1976. 5. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. Histological examination was compatible with the clinical features. Blaschko's lines represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Hypopigmentation along Blaschko’s lines defines hypomelanosis of Ito (HI). . Nevertheless, this should be considered in the differential diagnosis of any macular hyperpigmentation. As its name would suggest, the skin lesions occur along Blaschko lines. Blaschko's lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. Lichen planus (LP) is an inflammatory dermatosis that presents with pruritic papules, with LP lesions along the lines of Blaschko representing a rare variant. Somatosensation includes feedback from mechanoreceptors, thermoreceptors, proprioceptors, pain receptors, and chemoreceptors. On the face, Blaschko lines typically run perpendicularly on the forehead, along the lateral aspects of the nose, and down to the chin. Research Support, Non-U. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. To the best of our knowledge, a similar clinical presentation has been. 1. They were described and drawn by Blaschko 75 years ago. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. Blaschko’s lines were originally described by Dr. A dermatome is an area of skin that is supplied by a single spinal nerve. They represent lines of division of the two cell lines within the embryonic skin tissue. 5%~1% of the population worldwide 1. pattern remains speculative. The lines are the little rings of growth as we developed I guess - this reminds me of the line patterns Farina and Epicuticular Wax. These skin cells go rapidly in groups along these Blaschko’s lines as the fetus develops. Moreover, the clinical and histopathologic overlap between the entities of blaschkitis and lichen striatus is explored. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. Preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if detectable, is best shown in keratinocytes; and (3) the cytogenetic defect in epidermis may be directly responsible for the failure of pigmentation in HI. Lichen planus (LP) is an idiopathic inflammatory skin condition affecting the skin and mucosa. Bhutani et al. Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. He noticed that some of his patients had skin disorders that followed a specific. Blaschko′s lines are imaginary skin lines which various skin conditions are known to follow. We present this case and a brief review of the most commonly acquired linear eruptions following Blaschko's lines with the goal of expanding the histopathologic findings that may be encountered in adult blaschkitis. Moderate papillary dermal edema was present, along with focal homogenization of the collagen and. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. org. Recognition that a cutaneous lesion follows Blaschko lines may represent an important clue for the diagnosis. Paul Blaschko, who first described them in the early 1900s. 1. Case Description Patient 1 A 16-year-old Vietnamese male presented with a 1-year history of hair loss of the scalp. PDF. Prior to our report, a case of segmental and non-segmental vitiligo followed by Blaschko lines was never described, therefore we suggest the term "mixed vitiligo of Blaschko lines" to describe this entity. Cutaneous conditions can follow Blaschko's lines on the skin, which are thought to reflect patterns of cell migration and clonal expansion during embryonic development of the epidermis. Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. Dermatoses that follow Blaschko's lines are thought to be caused by a somatic mutation that takes place early in embryogenesis, resulting in a genotypic and phenotypic mosaicism. Males and females with certain skin conditions and other conditions will also show it under visible light or UV light. , incontinentia pigmenti). Lichen planus may affect the skin (cutaneous lichen planus), oral cavity (oral lichen planus), genitalia (penile or vulvar lichen planus), scalp (lichen planopilaris), nails, or esophagus.